Restless Legs Syndrome, What is restless legs syndrome (RLS)?, What is the treatment for RLS? Thehealthtime.com Restless Legs Syndrome What is restless legs syndrome (RLS)? Restless legs syndrome (also called RLS) is a condition in which your legs feel very uncomfortable when you are sitting or lying down. It affects both men and women and can occur at any age (including during childhood), but often worsens with age and becomes a problem for older adults....