Diethylstilbestrol, What is diethylstilbestrol?, Has DES caused any other problems? Thehealthtime.com Diethylstilbestrol What is diethylstilbestrol? Diethylstilbestrol (say: “die-eth-el-still-bess-troll”), or DES, is a man-made form of estrogen. Between 1938 and 1971, millions of women in the United States were given DES to prevent them from having a miscarriage or giving birth too early. DES was used in other countries until at least the early...